Background: Atopic dermatitis (AD) is a common skin disease. Therefore, these study asses to the relationship between AD severity and patients' HRQoL.

Methodology: This descriptive cross-sectional study carried out to evaluate the impact of Atopic Dermatitis on Health-related Quality of Life from March 2021 to February 2022. Severity was assessed by SCORAD scale. Patients' HRQoL was assessed using the DLQI scale. Chi-square test was used to examine the relationship between two qualitative variables. ANOVA was used to analyze the differences in SCORAD and DQLI. Statistical Package for Social Science 22 was used.

Results: Total 500 patients were selected among them 67% were below 25 years, 56% were male, 43% patients were illiterate, 82% of patients suffered from atopic dermatitis below 10 years and 85.4% had AD in the face. More than half of the patients had positive family history. Based on SCORAD scales, 42% of the patients had moderate diseases, 38% had mild and 20% severe disease and significant differences between some important variables and severe disease groups. According to DLQI scores observation, it had found that atopic dermatitis very largely effects on physical, mental and social life. From all ten questions of the DLQI, patients with higher disease severity had higher mean scores compared to those with moderate and mild disease severity.

Conclusion: Higher AD severity is associated with poorer HRQoL in AD patients. There is necessity to pay more attention to the psychological and social aspects in the patient with AD.