Comparative study between Platelet-rich plasma and corticosteroid in Osteoarthritis Knee Joint: A study in Zainul Haque Sikder Women's Medical College & Hospital, Dhaka, Bangladesh


Md. Johurul Hoque1 , Pervez Ahsan2 , Jabed Munjur Ahmed3 , Ananya Chowdhury4


Introduction: Platelet-rich plasma (PRP) uses injections of a concentration of a patient's own platelets to accelerate the healing of injured tendons, ligaments, muscles and joints. Corticosteroids (also known as steroids) are medicines that can be used to treat inflammation. Osteoarthritis disease is a painful condition that affects the articular cartilage of knee joint.
Objective: To compare the efficacy of PRP injection versus corticosteroid injection for Osteoarthritis Knee Joint. Materials and method: 25 male and 35 female (Mean Age 35.2 yrs.) presenting with Osteoarthritis Knee Joint where randomized to receive there PRP injection (1m1 PRP with 1ml of 2% xylocaine) given by a single surgeon. Patients were assessed before (Days 0) and after (Days 15, 30, 60) treatment for knee pain and function and knee strength. Patients where follow up 1 yr. to assess knee pain.
Result: In the present study of 60 patients there were 25 male and 35 female. In the present study of 60 patients the mean age was 35.2 years (Range between 15 to 55 years). Infection, tendon rupture and neurovascular damage where not found. Five patient reported pain for unto 3 days after PRP injection. In both groups knee pain improved dramatically after treatment, but the mode of improvement different. Compared with PRP injection. corticosteroid injection improve at a faster rate over the first 15 days and then started to decline slightly until 60 day. After PRP injection pain, function and knee strength improve steadily and where eventually better. PRP injection and Corticosteroid injection 30 days and faster rate 60 days of both group P-Value 0.0001. Almost high grater rate 30 days Group comparison with pain, function and knee strength patients.
Conclusion: PRP was more effective over the long term follow up period than corticosteroid injection in improving pain, function and knee strength. That's way we recommend this in a first line injection treatment because it is very simple, cheap and more effective.

Keywords: PRP Injection, Osteoarthritis Knee Joint, corticosteroid injection

  1. Associate Professor, Department of Orthopedic

    Z H Sikder Women's Medical College, Dhaka

  2. Professor, Department of Orthopedic

    Ibn Sina Medical College & Hospital, Dhaka

  3. Indoor Medical Officer, Orthopedics

    Z H Sikder Women's Medical College, Dhaka

  4. Indoor Medical Officer, Orthopedics

    Z H Sikder Women's Medical College, Dhaka

Volume 5, Number 1, January 2023
Page: 43-47