Plasma immunoglobulins (IgG, IgM, IgA) change in pregnancies of pre-eclampsia and eclampsia compared to normotensive pregnant and non-pregnant


Touhida Ahsan1 , Mahbuba Kawser2 , Sheikh Nazrul Islam, PhD3 , Monira Ahsan, PhD4 , Maksuda Kawser5


Background: Pre-eclampsia is an unpredictable pregnancy complication; severe pre-eclampsia affects the brain, evenseizures, and induces eclampsia. Materials and Methods: This study was conducted among a total of 155 subjectscomprising pre-eclampsia (n=44), eclampsia (n=47), normotensive pregnant (n=35), and normotensive non-pregnant(n=29) women. Plasma immunoglobulin content was determined by indirect Enzyme-Linked Immunosorbent Assay(ELISA). Significant differences in immunoglobulin contents across the groups were assessed by one-way analysisof variance (ANOVA) and between two groups by pair-sample t-tests. Results: Results showed significant (p<0.05)differences in IgG and IgM levels, while no significant changes were observed in the IgA level across groups. The IgGlevel was found to be increasing from non-pregnant (6.86±0.6 g/L) to the eclampsia (7.42±0.9 g/L) to pre-eclampsia(7.53±0.7 g/L); there had also significant (p<0.05) changes among eclampsia (7.42±0.9 g/L), normotensive pregnant(6.96±0.5 g/L), and non-pregnant (6.86±0.6 g/L). Furthermore, immunoglobulin M (IgM) had significant (p<0.05)variations among the complicated pregnancies (pre-eclampsia and eclampsia), normotensive pregnant (2.09±0.4), andnon-pregnant (2.64±0.2) women. At the same time, the highest amount of IgM was found in eclampsia (2.74±0.3 g/L)and the lowest in pre-eclamptic subjects (1.92±0.1 g/L). Conclusion: Significant alterations were observed in IgG andIgM levels across the groups, while changes (P>0.05) in the IgA level among the pre-eclamptic, eclamptic, pregnant,and non-pregnant women were found to be independent.

Keywords: Plasma immunoglobulins; Pre-eclampsia; Eclampsia; Normotensive pregnant; Non-pregnant

  1. Professor, Department of Obstetrics & Gynecology

    United Medical College, Gulshan, Dhaka

  2. Institute of Nutrition and Food Science

    University of Dhaka, Dhaka

  3. Professor, Institute of Nutrition and Food Science

    University of Dhaka, Dhaka

  4. Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy

    University of Dhaka, Dhaka

  5. Registrar, Department of Surgery,

    Sir Salimullah Medical College Mitford Hospital, Dhaka

Volume 6, Number 1, January 2024
Page: 3-9