Volume 8
Number 2, July 2026Neonatal Cholestasis: An Update
DOI: https://doi.org/10.47648/zhswmcj.2026.v0802.07
Kadir S1
Abstract
Neonatal cholestasis (NC) is a group of disorders marked by impaired bile formation or flow, resulting in conjugated hyperbilirubinemia during the neonatal period. It affects about 1 in 2,500 live births and is a significant cause of infant morbidity and mortality. Early diagnosis is crucial as several causes are treatable, and delays can lead to progressive liver damage. Biliary atresia is the most common surgically correctable cause and a leading indication for pediatric liver transplantation. Advances in molecular genetics and next-generation sequencing are enhancing diagnosis. This review summarizes current concepts in epidemiology, pathophysiology, etiology, clinical manifestations, diagnosis, management, and recent advances in neonatal cholestasis.
Keywords: Neonatal cholestasis, conjugated hyperbilirubinemia, biliary atresia, neonatal liver disease, genetic cholestasis, pediatric hepatology, liver transplantation
- Professor & Head of the Department of Paediatrics